When designing a play, I think it would be cool to be able to select a short list of several different defenses, then have your offensive play automatically execute against each one of those defense for a predetermined number of iterations.
E.g., practice play = "23 power run", executes against a, b, c, d, e, f, run defense, 5 times each; gather the stats for how my run play fairs against each defense, and generate a report.
Then you could run of a batch of tests for you play in rapid fire succession, and get a report back.